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February 10, 2003

Taisho to Launch "Pitaritto" Diarrhea Remedy With New
Active Ingredients for Painful Diarrhea

Taisho Pharmaceutical Co., Ltd. (President: Akira Uehara) is to launch "Pitaritto" a diarrhea remedy containing "loperamide hydrochloride" widely used for pharmaceutical purposes, together with the digestive enzyme "biodiastase 2000" and the bactericide "berberin chloride", on February 17, 2003.

Diarrhea occurs when the amount of water in the bowels increases or when bowel movement is excessive. "Loperamide hydrochloride", one of the active ingredients of "Pitaritto", curbs the secretion of intestinal fluid and slows bowel movement, to stop diarrhea. The digestive enzyme "biodiastase 2000" promotes the digestion of undigested food to relieve diarrhea due to over-indulgence in food or drink, while the bactericide "berberin chloride" suppress decomposition and fermentation in the bowels to relieve food and water poisoning.

"Loperamide hydrochloride" is a pharmaceutical substance used in many diarrhea remedies, with a highly effective action. "Pitaritto", which is the first OTC product to combine this ingredient with a digestive enzyme and a bactericide, is supplied in small film-coated tablet format, and offers powerful action against painful diarrhea.

"Pitaritto" is specially designed for adults (persons over the age of 15). Its launch means that, together with "Taisho Geri-Dome" featuring a bactericide, Taisho Pharmaceutical now offers two diarrhea remedies.

Product features
- Contains "loperamide hydrochloride", widely used for pharmaceutical purposes
- The first OTC drug to contain a digestive enzyme together with an bactericide for highly effective action in cases of painful diarrhea
- A diarrhea remedy specially designed for those over the age of 15

Product specification
Product name Pitaritto
Suggested retail price 12 tablet pack ¥1,450
Ingredients (in every 2 tablets)
Loperamide hydrochloride 0.5 mg
Berberin chloride 75 mg
Biodiastase 2000 45 mg
Vitamin B1 nitrate 7.5 mg
Vitamin B2 3 mg
Indications Diarrhea, diarrhea from over-indulgence in food or drink, diarrhea from catching cold during sleep, diarrhea with stomach cramps, food poisoning, water poisoning, loose stool
Dosage Take the appropriate number of tablets, as shown below, internally.
If diarrhea stops, do not repeat dose.
Allow an interval of at least 4 hours between doses.
Age Dosage Frequency
over 15 years 2 tablets Twice a day
under 15 years Do not administer to children under age 15.
Date of sale February 17, 2003
Expected sales ¥200 million (in 12 months from launch)