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February 7, 2002

Preser Cool Gel and Preser Kanpo Oral
Strengthening the Preser Hemorrhoid Treatment Line

Preser Cool Gel Preser Kanpo Oral
(Preser Cool Gel) (Preser Kanpo Oral)

Taisho Pharmaceutical Co., Ltd., (President: Akira Uehara) announced two additions to its Preser line of hemorrhoid treatments, Preser Cool Gel, a transparent topical gel, and Preser Kanpo Oral, which heals hemorrhoids while improving bowel movements, on February 12, 2002.

Preser Cool Gel is Japan's first transparent gel type hemorrhoid treatment. Smooth and non-sticky, it feels just cool enough when applied to affected areas and delivers a high level of both immediate and lasting therapeutic effects. This new treatment received high marks in clinical trials and patent applications have been submitted for the technology used to produce this gel type hemorrhoid treatment.

Preser Kanpo Oral is made of traditional Chinese herbs that heal hemorrhoids while easing the constipation that is one of the leading causes of hemorrhoids. Through the action of the traditional Otsuji-to herbal remedies from China, this treatment provides effective internal and external relief and aids in the healing of both hemorrhoids and anal fissures.

According to consumers surveyed by Taisho Pharmaceutical, individuals prone to hemorrhoids are alerted to having hemorrhoids by the discomfort of anal itching and swelling. Longtime sufferers from hemorrhoids "hate sticky feeling treatments" and "want quicker relief." Consumers also recognize that constipation is one of the causes of hemorrhoids and that unless constipation is relieved hemorrhoids are difficult to cure. The two new products described above have been created in response to these consumer needs.

The first treatment in the Preser series was launched in August, 1957. "Stop it and keep it stopped" Preser Ace is now the series' leading product, has won praise as both an effective remedy and an example of pharmaceutical manufacturing technology, and has long been established as one of the highest ranking products in its category. The new Preser Cool Gel and Preser Kanpo Oral bring new strength to the Preser series.

Preser Cool Gel

Product Features
1. Smooth, non-sticky clear gel
2. Outstanding therapeutic effects
3. Instantly feels cool when applied

Product Overview
Product name Preser Cool Gel
Retail price 800 yen (1 tube contains 15 g)
Active ingredients
(per 100 g)
 Chlorpheniramine 0.2g
 l-menthol 0.1g
 Lidocaine 3g
 Tetrahydrozoline 0.05g
 Benzalkonium chloride 0.05g
 Additives: polyoxyethylene castor oil
Indications For relief of itching, swelling, pain and bleeding associated with hemorrhoids and anal fissures and disinfection of the affected area.
Dosage Apply a suitable amount on affected areas around the anus, 1-3 times/day.
Date of release February 12, 2002
Expected sales 300 million yen in first year

Preser Kanpo Oral

Product Features
1. When taken internally, Otsuji-to improves bowel movements, lowering the risk of hemorrhoids.
2. Relieves all forms of hemorrhoids and anal fissures, both internal and external.
3. While preventing constipation that causes hemorrhoids, it also provides symptomatic relief.

Product Overview
Product name Preser Kanpo Oral
Retail price 2,700 yen for 30 packets
Active ingredients
(per daily dosage = three 2g packets)
 Otsuji-to extract 3.4g
 (below are the equivalent amounts of extract)
  Rhubarb 0.5g
  Cimicifuga Rhizome 0.75g
  Scutellaria Root 1.5g
  Bupleurum Root 2.5g
  Glycyrrhiza 1.0g
  Japanese Angelica Root 3.0g
Indications For relief of the following symptoms arising from hardened stools and tendency to constipation: hemorrhoids, anal fissures, constipation.
Dosage The following amounts should be taken before eating or with meals, i.e., within 2-3 hours of eating.
Age 15-plus 7-14 4-6 2-3 Under 2
Dose 1 packet 2/3 packet 1/2 packet 1/3 packet 1/4 packet
Frequency 3 times a day

[Notes] 1. Use only as directed in the prescribed amount.
2. Administer to children only under the supervision of a parent or guardian.
3. Do not give to children under the age of one unless absolutely necessary.
Date of release February 12, 2002
Expected sales 200 million yen